Tadhg Beirne is set to make his Six Nations debut against Wales on Saturday.
The 27-year-old will join James Ryan in the second row in the absence of the injured Iain Henderson.
Beirne has won four international caps to date, but will get his first taste of Six Nations action in the Cardiff decider.
Rob Kearney returns at full back after missing out against France through injury.
Sean O’Brien also comes in for Josh van der Flier, who missed out due to a groin injury.
Jack Conan will have to settle for a place on the bench despite his impressive cameo – and try – against Les Blues in Dublin.
Kieran Marmion is also named among the replacements alongside Conan, Quinn Roux, Jack Carty, Niall Scannell, Jordan Larmour, Andrew Porter, and Dave Kilcoyne.
Warren Gatland has kept faith with the same Wales team which maintained their 100% record against Scotland last week.
Liam Williams was forced off through injury against the Scots but is fit to start against Joe Schmidt’s visitors.
The hosts enter the clash against Ireland needing a victory to seal their first Grand Slam since 2012.
Wales: L Williams; G North, J Davies, H Parkes, J Adams; G Anscombe, G Davies; R Evans, K Owens, T Francis, A Beard, A W Jones (capt), J Navidi, J Tipuric, R Moriarty.
Replacements: E Dee, N Smith, D Lewis, J Ball, A Wainwright, A Davies, D Biggar, O Watkin.
Ireland: Rob Kearney; Keith Earls, Garry Ringrose, Bundee Aki, Jacob Stockdale; Johnny Sexton, Conor Murray; Cian Healy, Rory Best (capt), Tadhg Furlong; Tadhg Beirne, James Ryan; Peter O’Mahony, Sean O’Brien, Josh van der Flier, CJ Stander.
Replacements: Niall Scannell, Dave Kilcoyne, Andrew Porter, Quinn Roux, Jack Conan, Kieran Marmion, Jack Carty, Jordan Larmour.