Joe Schmidt has made four changes to the Ireland team ahead of Saturday’s clash with Japan in Shizuoka.
Jack Carty, Chris Farrell, Rob Kearney and Keith Earls all come into the team which beat Scotland in Ireland’s Pool A opener last week.
Carty and Farrell both came off the bench against Scotland, with veterans Kearney and Earls missing the all-European encounter through injury.
Johnny Sexton, Bundee Aki, Andrew Conway and Jordan Larmour are the players to make way, while Joey Carbery has returned from injury and has been named among the replacements.
Jack Conan was also due to start Saturday’s game against the host nation, but suffered an injury in training which has ruled him out.
27-year-old Carty – who will make just his second international start – will come in at out-half for Sexton, who picked up a quad injury in last week’s game, and has been given a rest.
Farrell will partner Garry Ringrose in the centre, having impressed after replacing Aki last weekend.
Rhys Ruddock has also been included on the bench.
Japan secured a bonus-point win over Russia in the tournament’s opening match.
Ireland: Rob Kearney; Keith Earls, Garry Ringrose, Chris Farrell, Jacob Stockdale; Jack Carty, Conor Murray, Cian Healy, Rory Best, Tadhg Furlong; Iain Henderson, James Ryan; CJ Stander, Josh Van Der Flier, Peter O’Mahony
Replacements: Sean Cronin, Dave Kilcoyne, Andrew Porter, Tadhg Beirne, Rhys Ruddock, Luke McGrath, Joey Carbery, Jordan Larmour